Picture of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Chris Eskiw

Chris Eskiw Assistant Professor

6E08 - Agriculture Building

Research Area(s)

  • Nutrigenomics
  • Molecular geontology
  • Genome organization


Food and Bioproduct Sciences

Research Interests

It has long been known that restricting nutrient/calorie intake promotes health and extends lifespan. However, the consequences of reduced nutrient uptake are not understood at the most basic level of our biology -- our genes. Understanding how our genes respond to nutrients is essential in order to design therapies/dietary strategies and to identify naturally occurring molecules found in foods to combat age-related disease and increase lifespan. The work in my laboratory aims to identify not only the genes involved in mediating health and longevity but also the mechanisms that drive this. Furthermore, my goal is to understand how nutrient availability and sensing impact genome folding, influencing in gene expression, leading to increased health and longevity.


  • Ph.D. (Cell Biology), University of Toronto
  • M.Sc. (Cell Biology), University of Saskatchewan
  • B.Sc. (Biological Sciences/Molecular Genetics), University of Alberta

Selected Publications

Salsman, J., Stathakis, A., Parker, E., Chung, D., Anthes, L.E., Koskowich, K.L., Lahsaee, S., Gaston, D., Kukurba, K.R., Smith, K.S., Chute, I.C., Léger, D., Frost, L.D., Montgomery, S.B., Lewis, S.M., Eskiw, C., and Dellaire, G.  2017.  PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.  Scientific Reports, (7): 45038.  https://doi.org/10.1038/srep45038

Gillespie, Z.E., Pickering, J., and Eskiw, C.H.  2016.  Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan.  Frontiers in Genetics, 7: 142.  https://doi.org/10.3389/fgene.2016.00142

Trost, B., Moir, C.A., Gillespie, Z.E., Kusalik, A., Mitchell, J.A., and Eskiw, C.H.  2015.  Concordance between RNA-sequencing data and DNA microarray data in transcriptome analysis of proliferative and quiescent fibroblasts.  Royal Society Open Science, 2(9): 150402.  https://doi.org/10.1098/rsos.150402

Mitchell, J.A., Clay, I., Umlauf, D., Chen C., Moir C.A., Eskiw, C.H., Schoenfelder, S., Chakalova, L., Nagano, T., and Fraser, P.J.  2012.  Nuclear RNA sequencing of the mouse erythroid cell transcriptome.  PLoS ONE,7(11): e49274.  https://doi.org/10.1371/journal.pone.0049274

Eskiw, C.H. and Fraser, P.J.  2011.  Ultra-structural study of transcription factories in mouse erythroblasts. Journal of Cell Science, 124(21): 3676-83.  https://doi.org/10.1242/jcs.087981

Mehta, I.S., Eskiw, C.H., Arican, H.D., Kill, I.R., and Bridger, J.M.  2011.  Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chmosome dynamics in Hutchinson-Gilford progeria syndrome cells.  Genome Biology, 12(8): R74.  https://doi.org/10.1186/gb-2011-12-8-r74

Eskiw, C.H., Cope, N. F., Clay, I., Schoenfelder, S., Nagano, T., and Fraser, P.J.  2011.  Transcription factories and nuclear organization of the genome.  Cold Spring Harbor Symposia on Quantitative Biology, sqb.2010.75.046.  https://doi.org/10.1101/sqb.2010.75.046

Cope, N.F., Fraser, P., and Eskiw, C.H.  2010.  The yin and yang of chromatin spatial organization.  Genome Biology, 11(3): 204-211. https://doi.org/10.1186/gb-2010-11-3-204

Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N.F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J.A., Umlauf, D., Dimitrova, D.S., Eskiw, C.H., Luo, Y., Wei, C.-L., Ruan, Y., Bieker, J.J., and Fraser P.  2010.  Preferential associations between co-regulated genes reveal a transcriptional interactome.  Nature Genetics, 42(1): 53-61.  https://doi.org/10.1038/ng.496