Chris Eskiw

Chris Eskiw

Assistant Professor

Departments: Food and Bioproduct Sciences

Research:

My research area focuses on how nutrient availability and sensing impacts the aging process by altering genome function and organization.

Background:

It has long been known that restricting nutrient/calorie intake promotes health and extends lifespan. However, the consequences of reduced nutrient uptake are not understood at the most basic level of our biology -- our genes. Understanding how our genes respond to nutrients is essential in order to design therapies/dietary strategies and to identify naturally occurring molecules found in foods to combat age-related disease and increase lifespan. The work in my laboratory aims to identify not only the genes involved in mediating health and longevity but also the mechanisms that drive this. Furthermore, my goal is to understand how nutrient availability and sensing impact genome folding, influencing in gene expression, leading to increased health and longevity.

Publications:

  1. Mitchell, J.A., Clay, I., Umlauf, D., Chen C., Moir C.A., Eskiw, C.H., Schoenfelder, S., Chakalova, L., Nagano, T., and Fraser, P.J., (2012) Transcriptome characterization through comparative genome-wide analysis of nuclear RNA and RNAPII association in erythroid cells. PLoS One. 2012;7(11):e49274.
  2. Bridger, J.M., Eskiw, C.H., Makarov, E.M., Tree, D., Kill, I.R. (2011) Progeria research day at Brunel University. Nucleus, Nov 1;2(6).
  3. Eskiw, C.H.* and Fraser, P.J. (2011) Ultra-structural study of transcription factories in mouse erythroblasts. J Cell Sci. Nov 1;124(Pt 21):3676-83. * Corresponding author
  4. Mehta, I.S., Eskiw, C.H., Arican, H.D., Kill, I.R., and Bridger, J.M. (2011) Farnesyltransferase Inhibitor Treatment restores Chromosome Territory Positions and Active Chromosome Dynamics in Hutchinson-Gilford Progeria Syndrome Cells. Genome Biol. Aug 12;12(8):R74.
  5. Eskiw, C.H., Cope, N. F., Clay, I., Schoenfelder, S., Nagano, T., and Fraser, P.J. (2011) Transcription Factories and Nuclear Organization of the Genome. Cold Spring Harb. Symp. Quant. Biol. 2011 Apr 5.
  6. Pink, R. Eskiw, C. H., Carter, D. (2010) Analysis of β-globin Chromatin Micro-environment using a Novel 3C Variant, 4Cv. PLoS One. Sep 29;5(9). pii: e13045.
  7. N. F. Cope, Fraser, P., Eskiw, C.H.*  (2010) The yin and yang of chromatin spatial organization.  Genome Biology 11:204-211  *Corresponding Author
  8. Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N.F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J.A., Umlauf, D., Dimitrova, D.S., Eskiw, C. H., Luo, Y., Wei, Ruan, C.Y., Bieker, J.J., and Fraser P.J. (2010) Preferential associations between co-regulated genes reveal a transcriptional interactome. Nature Genetics Jan;42(1):16-7.
  9. Eskiw, C. H., and Fraser, P.J. (2009) Inverted rod cells see the light.  Nature Cell Biol. Jun 6 (11):68
  10. Carter, D.R., Eskiw, C.H., and Cook, P.R.C. (2008) Transcription Factories. Biochem Soc Trans. Aug;36(Pt 4):585-9.
  11. Eskiw, C. H., Rapp, A., Carter, D.R. and Cook, P.R. (2008) RNA polymerase II activity is located on the surface of protein-rich transcription factories. J Cell Sci. Jun 15;121(Pt 12):1999-2007.
  12. Osborne, C., and Eskiw, C. H. (2008) Where shall we meet? A role for genome    organisation and nuclear sub-compartments in mediating interchromosomal interactions. J. Cell Biochem. Apr 2;104(5):1553-1561
  13. Block, G.J., Eskiw, C. H., Dellaire, G. and Bazett-Jones, D.P.  (2006) Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies. Mol Cell Biol. 2006 Dec;26(23):8814-25.
  14. Bartlett, J., Blagojevic, J., Carter, D., Eskiw, C., Fromaget, M., Job, C., Shamsher, M., Trindade, I. F., Xu, M. and Cook, P. R.  (2006) Specialized transcription factories.  Biochem Soc Symp. (73):67-75